They note that studies of vitamin B6 supplementation in schizophrenia have been inconclusive, and claim that benefits may become limited to patients who have low vitamin B6 levels in conjunction with carbonyl stress. Certified from medwireNews with authorization from Springer Healthcare Ltd. All privileges reserved. Neither of the ongoing celebrations endorse or recommend any commercial products, services, or equipment.. Carbonyl stress suggests technique for treatment-resistant schizophrenia By Eleanor McDermid, Senior medwireNews Reporter Patients with schizophrenia who’ve enhanced carbonyl tension have clinical features connected with treatment resistance, say researchers. Mitsuhiro Miyashita and team used two biomarkers to identify patients with carbonyl tension: high plasma pentosidine and low pyridoxal levels .It ensures complete protection and does not cause any relative side effect.. Chromosome 3p21.1 locus contains common genetic risk for bipolar disorder One of the biggest problems in psychiatric genetics offers been to replicate results across large studies. Researchers at King's College London, Institute of Psychiatry have now performed one of the largest ever genetic replication studies of bipolar affective disorder, with 28,000 subjects recruited from 36 different research centers. Their results provide compelling evidence that the chromosome 3p21.1 locus contains a common genetic risk for bipolar disorder, the PBRM1 gene. The locus at 3p21.1 provides been previously associated with depressive disorder and schizophrenia also.