On the other hand, PPX isn’t expected to end up being effected by MGMT expression. Therefore, the combination of RT and PPX could be more effective than standard TMZ/RT in patients with MGMT positive GBM. Â The poster from the conference is available at.. Cell Therapeutics announces preliminary results of stage II OPAXIO study for high-grade gliomas Cell Therapeutics, Inc. The study was provided by Drs. Suriya Jeyapalan, Heinrich Elinzano and Mark Goldman, Assistant Professors of Neurology and Neurosurgery, Brown University Oncology Group at the 2010 Scientific Meeting of the Society of Neuro-Oncology in Montreal, Canada.Being overweight or obese is definitely implicated with insulin resistance and type 2 diabetes and in addition raises the chance for heart disease, cancer and stroke. The Joslin group studied ‘knockout’ cell lines of brown preadipocytes that lacked insulin receptor substrates numbered 1 through 4, which will be the first guidelines in insulin signaling in the cell. In cell lines lacking IRS1, the precursors failed to become mature brown excess fat cells. Importantly, when the gene was added by them for IRS1 back to the knockout cells, the precursors recovered most of their capability to differentiate into brown fat cells. Varying results happened with the knockout of genes for IRS2, IRS3 and IRS4. Using DNA chips to investigate these cells, a solid genetic pattern emerged that predicted the potential of precursors to differentiate into mature brown fats cells.