Collaborative research yields a wiring map on how TB responds to changes in environment Despite decades of research on the bacterium that causes tuberculosis , scientists have not had a thorough understanding of how the bacterium is wired to adjust to changing conditions in the host. Now, researchers at Stanford University, Seattle BioMed, Boston University and the Broad Institute, Max Planck Institute of Biology in Berlin, Germany, Caprion Proteomics Inc. In Montreal, Canada, Brigham and Woman's Hospital , and Colorado State University took the first steps toward a complete representation of the regulatory network for Mycobacterium tuberculosis.Antibiotic resistance is an evergrowing problem worldwide. In European countries, 39 percent of invasive bacterias had been resistant to penicillin in 2006 and needless antibiotic prescribing, particularly for respiratory illnesses, offers been blamed for raising antibiotic resistance. Some evidence also suggests that most antibiotic prescriptions usually do not help these patients get better any quicker, although the results are still unclear. So a team of researchers set out to describe variation in antibiotic prescribing for acute cough across European countries, and its own impact on recovery.