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Apolipoproteins are responsible for depositing and distributing cholesterols and other lipids in the brain. They can be found in three types: apoE2, apoE3 and apoE4. People who have the gene that generates apoE4 are in higher risk for amyloid plaques and neurofibrillary tangles, the hallmarks of Alzheimer's. But just how the proteins itself plays a part in Alzheimer's isn’t known. This study suggests that outside the body, where the protein could be separated from the cholesterols it normally carries, apoE4 is beneficial to advertise neuron growth actually.